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To gain insight into the potential clinical relevance of this polymorphism in terms of breast cancer hormone dependence, we compared the 265 cytosols for their 3H tamoxifen aziridine and 3H estradiol binding capacities using the above mentioned method and the conventional dextran coated charcoal assay lasix drip Bone fractures and osteoporosis were reported more frequently following treatment with letrozole whereas tamoxifen was associated with a higher risk for endometrial proliferation and endometrial cancer