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Hydroxychloroquine has been studied as a potential preventive therapy for COVID-19 in high-risk populations, such as healthcare workers or close contacts of infected individuals. hydroxychloroquine and rheumatoid arthritis While some observational studies have suggested potential benefits in reducing the risk of infection or disease severity, randomized controlled trials have yielded mixed results. Further research is needed to determine the role of hydroxychloroquine in COVID-19 prevention and identify populations that may benefit most from prophylactic treatment.