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For starters, the overall quit rates were pretty lousy. At the six month follow-up only 7.3% of the nicotine e-cigarette group and 5.8% of the patch group were still conventional smoke free.** That’s lower than the authors expected and lower than nicotine patches have fared in previous studies. This being an e-cigarette trial, it’s possible that the people assigned to the nicotine patch were hoping to try these exciting e-cigarettes they’d been hearing about and got discouraged once they found out the were in the patch group. I’m also a little skeptical about the use of the nicotine-free electronic cigarette as a placebo. A big part of the appeal of conventional smoking is whole inhaling/exhaling action, not just the nicotine. Thus a nicotine-free e-cigarette is hardly the same kind of placebo as a sugar pill in a drug trial. And indeed that “placebo” group wasn’t that far behind in quitting, with 4% still abstaining from conventional smokes at the 6-month mark.