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Treatment of the MCF7 TAMR cells with the combination of dasatinib and 4 OHT resulted in nuclear shuttling of ER, potentially allowing it to become a classical target for 4 OHT, which associated with a decrease in pAKT and pERK1 2, together with a significant reduction in proliferation topical propecia The role of RARО±1 in mediating the action of apo ER is strongly evident from the following observations i In hormone depleted cells, apo ER maintained the basal expression level of RARО±1 but was not itself regulated by RARО±1; ii The regulation of RARО±1 by apo ER was insensitive to tamoxifen; iii Knocking down RARО±1 negatively impacted the basal cell cycle progression and restoring basal apo RARО±1 levels rescued basal level cell division following depletion of ER; iv Apo RARО±1 independently regulated a complement of genes in a manner that strongly favored cell division similar to their regulation by apo ER