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The characteristics of the 105 patients included in these analyses were as follows median age, 62 years; median disease free interval DFI, 523 days; median ER level, 44 fmol mg; median PgR level, 52 fmol mg; soft tissue dominant disease, 37 patients 35; bone dominant disease, 36 patients 34; visceral dominant disease, 32 patients 31; one site of disease, 60 patients 58; two or more sites of disease, 45 patients 42; treatment with megestrol acetate, 62 patients 59; treatment with tamoxifen, 43 patients 41 doxycycline heartworm